Saracens have confirmed the nature of the injuries sustained by England trio Mako Vunipola, Billy Vunipola and Nick Isiekwe, expecting all three forwards to be set for spells on the sideline.
The club has confirmed that the youngest of the trio, 20-year-old Isiekwe, suffered an ankle sprain during the club's Champions Cup victory over Glasgow yesterday and is waiting to be assessed by a consultant with regards to the full extent of the injury.
Billy Vunipola has suffered a fracture to his left forearm and is set for a 12-week recovery period. A fracture sustained to the opposite arm the barnstorming number eight fractured twice last season.
The final of the threesome, loosehead prop Mako Vunipola, has picked up a calf strain, with Saracens commenting only that "his progress will be monitored."
The injuries to the Vunipola brothers places England head coach Eddie Jones in a precarious situation in the forwards, with his stocks at loosehead prop and number eight at an all-time low.
With Mako injured and potentially out for at least the start of England's November Internationals campaign, Jones is now without the top three loosehead props in the country, with Joe Marler announcing his retirement from Test rugby earlier this month and Leicester Tigers' Ellis Genge yet to return from knee ligament surgery.
Jones is also without one of last season's most promising yong looseheads, with Bath's Beno Obano, 23, also still out with knee ligament damage. Wasps' former captain Matt Mullan is another name missing from Jones' options in the number one jersey, having also suffered a knee injury last February.
Jones will likely turn the Exeter duo of Alec Hepburn and Ben Moon, while 22-year-old Quins man, and understudy to Marler, Lewis Boyce could enjoy a squad return after his initial call-up to England's Six Nations squad earlier this year.
At the back of the scrum, England are set to be stripped of their first three options at number eight, with Billy Vunipola out with yet another injury, Wasps' Nathan Hughes expected to receive a ban for striking Gloucester's Lewis Ludlow a fortnight ago and Exeter dynamo Sam Simmonds racing to return to fitness before the season's end after yet another knee injury within English ranks.
Bath's Zach Mercer stands in pole position to don the eight jersey, while Gloucester's Ben Morgan may earn a first squad inclusion under Jones after an impressive start to the season.
Wasps' flanker Brad Shields may also come into consideration as a replacement for Billy Vunipola, Hughes and Simmonds, having spent ample time at the back of the Hurricanes' scrum in Super Rugby.