Jack Nowell's Six Nations campaign is under threat following a hamstring injury sustained with England.
Nowell, 25, started for England against South Africa and Japan earlier this month but is expected to be sidelined for eight weeks after suffering a hamstring injury sustained whilst training ahead of the national side's final November clash with Australia.
"Jack's got a pretty significant hamstring tear," Exeter Chiefs rugby director Rob Baxter told the club's official website.
"It's one of those injuries which is likely to be around the eight-week mark, give or take a week, depending on how his rehab goes.
"Ironically, he should be back in time to fight for a place in the Six Nations!"
The 29-times-capped international, who featured against Japan at outside centre, will miss Exeter Chiefs'
Champions Cup poll games, in which the 2017 Premiership champions will face home and away fixtures against league rivals Gloucester, against Castre at Sandy Park and Munster in Ireland.
Nowell will also be missing for a number of crucial Premiership clashes against playoff competitors Saracens next month. Both teams currently sit on 38 points apiece at the top of the Premiership table, meeting for the first time since Saracens' victory in the Premiership final last May.