In the final preparations prior to Thursday's team announcement, England head coach Eddie Jones has culled his 36-man training squad to a final 25-man match-day squad to face South Africa this weekend (Saturday, 3rd November).
The list of 11 players cut from contention include England's most capped fullback Mike Brown, Gloucester number eight Ben Morgan and Bath's fit-again openside flanker Sam Underhill.
Players released ahead of Springbok clash
Ted Hill (flanker/Worcester Warriors)
Courtney Lawes (Lock/Northampton Saints) *to remain with squad for rehab
Ben Morgan (Backrow/Gloucester)
Michael Rhodes (Backrow/Saracens)
Nick Schonert (Prop/Worcester Warriors)
Sam Underhill (Backrow/Bath Rugby)
Mike Brown (Fullback/Harlequins)
Joe Cokanasiga (Wing/Bath Rugby)
Nathan Earle (Wing/Harlequins)
Alex Lozowski (Centre/Saracens)
Richard Wigglesworth (Scrum-half/Saracens)
With Morgan returning to England to return to Gloucester, 21-year-old Bath number eight Zach Mercer is in pole position for a shot at a first England cap and a starting role within Jones' pack.
Mercer is set to be joined by Sale Sharks openside flanker Tom Curry in the backrow, with either of Brad Shields, Mark Wilson or Maro Itoje filling in at blindside in the absence of injured flanker and former captain Chris Robshaw.
Long-time absentees Chris Ashton and Manu Tuilagi are also inline for inclusions in England's starting XV to take to the Twickenham field this weekend, with both men displaying fine form during their latest performances.
Ashton's role in the Barbarians side that dismantled England at Twickenham last May and Tuilagi's barnstorming performance in Leicester Tigers' Champions Cup victory over Scarlets a fortnight ago will stand as firm reminders of what the attacking pedigree the duo can provide England.
Both Ashton and Tuilagi last started a test match four years ago, during England's tour of New Zealand in 2014 and could return to face the back-to-back World Cup winners at Twickenham next weekend 9Saturday 10th November).
England's 25-man squad to face the Springboks.
Tom Curry (Flanker/Sale Sharks)
Charlie Ewels (Lock/Bath Rugby)
Jamie George (Hooker/Saracens)
Dylan Hartley (Hooker/Northampton Saints) *co-captain
Alec Hepburn (Prop/Exeter Chiefs)
Maro Itoje (Lock/Saracens)
George Kruis (Lock/Saracens)
Zach Mercer (Backrow/Bath Rugby)
Ben Moon (Prop/Exeter Chiefs)
Brad Shields (Flanker/Wasps)
Kyle Sinckler (Prop/Harlequins)
Elliot Stooke (Lock/Bath Rugby)
Harry Williams (Prop/Exeter Chiefs)
Mark Wilson (Flanker/Newcastle Falcons)
Chris Ashton (Wing/Sale Sharks)
Danny Care (Scrum-half/Harlequins)
Elliot Daly (Fullback/Wasps)
Owen Farrell (Fly-half/Saracens) *co-captain
George Ford (Fly-half/Leicester Tigers)
Jonny May (Wing/Leicester Tigers)
Jack Nowell (Wing/Exeter Chiefs)
Henry Slade (Centre/Exeter Chiefs)
Ben Te'o (Centre/Worcester Warriors)
Manu Tuilagi (Centre/Leicester Tigers)
Ben Youngs (Scrum-half/Leicester Tigers)
Ali Stokes' England team to tackle the Springboks
Given the current injury crisis plaguing Eddie Jones's squad, it would be a shame not to use the Springbok Test as a chance to try a few new combinations, while reuniting some old ones.
Following injuries to Joe Launchbury and Courtney Lawes, George Kruis would do well to return to England's starting XV to combine with Saracens teammate Jamie George in an attempt to nail down the set-piece, while simultaneously allowing Maro Itoje to return to his rambunctious self.
Given the exclusion of potentially suspended centre Alex Lozowski and Manu Tuilagi's recent return to top form, the return of the George Ford-Owen Farrell 10-12 axis could be crucial in correctly managing and utilising the Samoan-born centre in his first Test return.
1. Ben Moon
2. Jamie George
3. Harry Williams
4. Maro Itoje
5. George Kruis
6. Mark Wilson
7. Tom Curry
8. Zach Mercer
9. Danny Care
10. George Ford
11. Jonny May
12. Owen Farrell (c)
13. Manu Tuilagi
14. Chris Ashton
15. Elliot Daly
Subs: 16. Dylan Hartley, 17. Alec Hepburn, 18. Kyle Sinckler, 19. Charlie Ewels, 20. Brad Shields, 21. Ben Youngs, 22. Henry Slade, 23. Jack Nowell
In the ensuing fixtures against Japan and Australia, I would be keen to see a centre combination of a fit-again Ben Te'o and Tuilagi, with Farrell returning to his original position of fly-half; with the exciting prospect of Ashton running his predator-like support lines off the back of the muscular duo's midfield punches.